Methane/phenol/toluene hydroxylase (IPR003430)

Short name: Phenol_Hydrox

Overlapping homologous superfamilies

Family relationships


Bacterial phenol hydroxylase (EC: is a multicomponent enzyme that catabolises phenol and some of its methylated derivatives. This family contains both the P1 and P3 polypeptides of phenol hydroxlase and the alpha and beta chain of methane hydroxylase protein A. Methane hydroxylase protein A (EC: is responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyses the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds. Also included in this family is toluene-4-monooxygenase system subunits alpha and beta (EC:1.14.13), which hydroxylates toluene to form P-cresol [PMID: 1885512], and subunits alpha and beta of the alkene monooxygenase multicomponent enzyme system (EC: from Xanthobacter autotrophicus, which catalyzes the O2- and NADH-dependent epoxidation of short chain (C2 to C6) alkenes to their corresponding epoxides [PMID: 9312093].

GO terms

Biological Process

GO:0006725 cellular aromatic compound metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.