MgtC/SapB/SrpB/YhiD family (IPR003416)

Short name: MgtC/SapB/SrpB/YhiD_fam

Overlapping homologous superfamilies


Family relationships



This entry includes a group of transmembrane proteins, including MgtC, SapB, SrpB and YhiD from bacteria.

The MgtC protein is found in an operon with the Mg2+ transporter protein MgtB. However, MgtC is not a Mg2+ transporter [PMID: 9673265, PMID: 16855249]. The expression of MgtC is a virulence factor required for growth in low Mg2+ medium and for intramacrophage survival [PMID: 17176255]. MgtC may be involved in regulating membrane potential by activating Na+/K+-ATPase [PMID: 9673265, PMID: 16855249].

YhiD from E. coli is an integral membrane protein related to MgtC. It has been suggested to be an essential component for the Mg2+ uptake system in E. coli [PMID: 19798051].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.