Type II secretion system protein I domain (IPR003413)

Short name: T2SS_protein-I_dom

Overlapping homologous superfamilies


Domain relationships



The bacterial general secretion pathway (GSP) is involved in the export of proteins. Five secretion pathways that permit the secretion of soluble proteins have been described [PMID: 15223057]. This group consists of type II secretion system protein I (sometimes known as general secretion pathway protein I). The Type II secretion system is responsible for the transport of proteins across the outer membrane first exported to the periplasm by the Sec or Tat translocon in Gram-negative bacteria. Like members of the T2SJ family, members of the T2SI family are pseudopilins containing prepilin signal sequences [PMID: 8407845].

This entry represents a domain that does not include the T2SI prepilin signal sequence.

GO terms

Biological Process

GO:0015628 protein secretion by the type II secretion system

Molecular Function

GO:0008565 protein transporter activity

Cellular Component

GO:0015627 type II protein secretion system complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.