Ammonia monooxygenase/particulate methane monooxygenase, subunit A (IPR003393)

Short name: NH3_CH4_mOase_A

Overlapping homologous superfamilies

Family relationships


Ammonia monooxygenase and the particulate methane monooxygenase are both integral membrane proteins, occurring in ammonia oxidisers and methanotrophs respectively, which are thought to be evolutionarily related [PMID: 7590173]. These enzymes have a relatively wide substrate specificity and can catalyse the oxidation of a range of substrates including ammonia, methane, halogenated hydrocarbons and aromatic molecules [PMID: 12209257]. These enzymes are composed of 3 subunits - A (IPR003393), B (IPR006833) and C (IPR006980) - and contain various metal centres, including copper. Particulate methane monooxygenase from Methylococcus capsulatus str. Bath is an ABC homotrimer, which contains mononuclear and dinuclear copper metal centres, and a third metal centre containing a metal ion whose identity in vivo is not certain[PMID: 15674245].

The A subunit from Methylococcus capsulatus str. Bath resides primarily within the membrane and consists of 7 transmembrane helices and a beta-hairpin which interacts with the soluble region of the B subunit. A conserved glutamate residue is thought to contribute to a metal centre [PMID: 15674245].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.