Protein patched/dispatched (IPR003392)

Short name: Ptc/Disp

Overlapping homologous superfamilies


Family relationships


This entry includes protein patched (ptc) and protein dispatched (disp) from Drosophila melanogaster, and the Niemann-Pick C1 protein from humans.

Protein patched is a receptor for the morphogene Sonic Hedgehog [PMID: 12372301]. It associates with the smoothened protein to transduce hedgehog signals, leading to the activation of wingless, decapentaplegic and patched itself. It participates in cell interactions that establish pattern within the segment and imaginal disks during development [PMID: 8049466]. The mouse homologue may play a role in epidermal development. The human Niemann-Pick C1 protein, defects in which cause Niemann-Pick type II disease, is also a member of this family. This protein is involved in the intracellular trafficking of cholesterol, and may play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural functional integrity of nerve terminals [PMID: 19563754].

Protein dispatched may act by some mechanism to present or release the Hh signal for stimulation of distant target cells [PMID: 12372301].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.