Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase (IPR003386)

Short name: LACT/PDAT_acylTrfase

Overlapping homologous superfamilies

Family relationships



Lecithin:cholesterol acyltransferase (LACT), also known as phosphatidylcholine-sterol acyltransferase (EC:, is involved in extracellular metabolism of plasma lipoproteins, including cholesterol. It esterifies the free cholesterol transported in plasma lipoproteins, and is activated by apolipoprotein A-I. Defects in LACT cause Norum and Fish eye diseases.

This family also includes phospholipid:diacylglycerol acyltransferase (PDAT)(EC:, which is involved in triacylglycerol formation by an acyl-CoA independent pathway. The enzyme specifically transfers acyl groups from the sn-2 position of a phospholipid to diacylglycerol, thus forming an sn-1-lysophospholipid [PMID: 12963726].

GO terms

Biological Process

GO:0006629 lipid metabolic process

Molecular Function

GO:0008374 O-acyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.