InterPro

This entry represents a group of conserved proteins from fungi, plants to animals. They are transmembrane proteins. Proteins in this entry include budding yeast Erv14/15, Drosophila Cornichon and human CNIH1/2/3/4.

The drosophila cornichon protein (gene: cni), the founding member of this family, is an integral component of the COPII-coated vesicles that mediate cargo export from the yeast endoplasmic reticulum (ER) [PMID: 16396907]. It is required in the germline for dorsal-ventral signalling. The dorsal-ventral pattern formation involves a reorganisation of the microtubule network correlated with the movement of the oocyte nucleus, and depending on the initial correct establishment of the anterior-posterior axis via a signal from the oocyte produced by cornichon and gurken and received by torpedo protein in the follicle cells [PMID: 7540118].

Erv14 is a COPII-coated vesicle protein involved in vesicle formation and incorporation of specific secretory cargo. It is required for axial budding [PMID: 9732282, PMID: 17298976].

CNIH1 is involved in the selective transport and maturation of TGF-alpha family proteins [PMID: 17607000].