Herpesvirus US22-like (IPR003360)

Short name: Herpes_US22-like

Family relationships



Herpesviruses are large and complex DNA viruses, widely found in nature. Human cytomegalovirus (HCMV), an important human pathogen, defines the betaherpesvirus family. Mouse cytomegalovirus (MCMV) and rat cytomegalovirus serve as biological model systems for HCMV. HCMV, MCMV, and rat CMV display the largest genomes among the herpesviruses and are essentially co-linear over the central 180 kb of the 230-kb genomes. Betaherpesviruses, which include the CMVs as well as human herpesviruses 6 and 7, differ from alpha- and gammaherpesviruses by the presence of additional gene families such as the US22 gene family, which are mainly clustered at the ends of the genome. The US22 family was first described in HCMV. This gene family comprises 12 members in both HCMV and MCMV and 11 in rat CMV [PMID: 12719548].

Members of the US22 gene family are characterised by stretches of hydrophobic and charged residues as well as up to four conserved sequence motifs which are specific for betaherpesviruses. Motif I differs between the HCMV US and UL family members [PMID: 8709220]. Motifs I and II have consensus sequences, while motifs III and IV are less well defined but have stretches of non-polar residues [PMID: 10405367, PMID: 8523552]. Members of this gene family are widely divergent in function and their involvement in viral replication [PMID: 12719548].

This entry contains US22 family members from the Cytomegalovirus, Muromegalovirus and the Roseolovirus taxonomic groups.

The name sake of this family US22 is an early nuclear protein that is secreted from cells [PMID: 1321206]. The US22 family may have a role in virus replication and pathogenesis [PMID: 10405367].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.