Domain

Phosphotransferase system, EIIC (IPR003352)

Short name: PTS_EIIC

Domain relationships

Description

The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The PTS catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The general mechanism of the PTS is the following: a phosphoryl group from phosphoenolpyruvate (PEP) is transferred to enzyme-I (EI) of PTS which in turn transfers it to a phosphoryl carrier protein (HPr). Phospho-HPr then transfers the phosphoryl group to a sugar-specific permease which consists of at least three structurally distinct domains (IIA, IIB, and IIC) [PMID: 1537788] which can either be fused together in a single polypeptide chain or exist as two or three interactive chains, formerly called enzymes II (EII) and III (EIII). The IIC domain catalyzes the transfer of a phosphoryl group from IIB to the sugar substrate.

PTS systems commonly occur in bacteria. An archaeal version has also been discovered [PMID: 22493022]. This entry identifies both the bacterial family members and archaeal homologues.

GO terms

Biological Process

GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system

Molecular Function

GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
Pfam