Trehalose-phosphatase (IPR003337)

Short name: Trehalose_PPase

Overlapping homologous superfamilies

Family relationships


Trehalose-phosphatases EC: catalyse the de-phosphorylation of trehalose-6-phosphate to trehalose and orthophosphate. Trehalose is a common disaccharide of bacteria, fungi and invertebrates that appears to play a major role in desiccation tolerance. A pathway for trehalose biosynthesis may also exist in plants [PMID: 9681009]. The trehalose-phosphatase signature is found in the C terminus of trehalose-6-phosphate synthase EC: adjacent to the trehalose-6-phosphate synthase domain (see IPR001830). It would appear that the two equivalent genes in the Escherichia coli otsBA operon: otsA, the trehalose-6-phosphate synthase and otsB, trehalose-phosphatase (this family) have undergone gene fusion in most eukaryotes [PMID: 8045430].

GO terms

Biological Process

GO:0005992 trehalose biosynthetic process

Molecular Function

GO:0003824 catalytic activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.