Mycolic acid cyclopropane synthase (IPR003333)

Short name: Mycolic_cyclopropane_synthase

Overlapping homologous superfamilies

Family relationships



This entry represents mycolic acid cyclopropane synthases and related enzymes, including CmaA1, CmaA2 (cyclopropane mycolic acid synthase A1 and A2), MmaA1-4 (methoxymycolic acid synthase A1-4) and tuberculostearic acid methyltransferase UfaA1. All are thought to be S-adenosyl-L-methionine (SAM) utilising methyltransferases [PMID: 11756461]. This entry also includes S-adenosylmethionine-dependent methyltransferase UmaA from Mycobacterium tuberculosis, which is a methyltransferase that modifies short-chain fatty acids [PMID: 23435098]; and sphingolipid C9-methyltransferase, which catalyses the methylation of sphingoid component of glucosylceramides [PMID: 20019081].

Mycolic acid cyclopropane synthase or cyclopropane-fatty-acyl-phospholipid synthase (CFA synthase) EC: catalyses the reaction:

S-adenosyl-L-methionine + phospholipid olefinic fatty acid -> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.

The major mycolic acid produced by Mycobacterium tuberculosis contains two cis-cyclopropanes in the meromycolate chain. Cyclopropanation may contribute to the structural integrity of the cell wall complex [PMID: 7592990].

GO terms

Biological Process

GO:0008610 lipid biosynthetic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.