Domain

TerD domain (IPR003325)

Short name: TerD

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins [PMID: 10203839, PMID: 23044854]. It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium binding sites [PMID: 23044854, PMID: 21112337] depending on the conservation of aspartates [PMID: 23044854]. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways [PMID: 23044854].

TerD domain is also found in cAMP binding protein, chemical-damaging agent resistance proteins and general stress proteins. The cellular Slime mould, Dictyostelium discoideum, contains a cAMP-binding protein, CABP1, which is composed of two subunits. The C-terminal half of these subunits contain this domain [PMID: 2176639].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
Pfam