Domain

TerD domain (IPR003325)

Short name: TerD

Domain relationships

None.

Description

The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins [PMID: 10203839, PMID: 23044854]. It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium binding sites [PMID: 23044854, PMID: 21112337] depending on the conservation of aspartates [PMID: 23044854]. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways [PMID: 23044854].

TerD domain is also found in cAMP binding protein, chemical-damaging agent resistance proteins and general stress proteins. The cellular Slime mould, Dictyostelium discoideum, contains a cAMP-binding protein, CABP1, which is composed of two subunits. The C-terminal half of these subunits contain this domain [PMID: 2176639].

GO terms

Biological Process

GO:0006950 response to stress

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam