E2F/DP family, winged-helix DNA-binding domain (IPR003316)

Short name: E2F_WHTH_DNA-bd_dom

Overlapping homologous superfamilies

Domain relationships



This entry represents the DNA-binding domain of the E2F and DP proteins, which have a fold related to the winged-helix DNA-binding motif [PMID: 10090723]. The mammalian transcription factor E2F plays an important role in regulating the expression of genes that are required for passage through the cell cycle. Multiple E2F family members have been identified that bind to DNA as heterodimers, interacting with proteins known as DP - the dimerisation partners [PMID: 7739537].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003700 DNA-binding transcription factor activity

Cellular Component

GO:0005667 transcription factor complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.