Filaggrin (IPR003303)

Short name: Filaggrin

Overlapping homologous superfamilies


Family relationships



Filaggrins are filament-associated proteins that interact with keratin intermediate filaments of terminally differentiating mammalian epidermis via disulphide bond formation [PMID: 2740331]. They show wide species variations and their aberrant expression has been implicated in a number of keratinising disorders. The proteins are synthesised as large, insoluble, highly- phosphorylated precursors, containing multiple tandem repeats of 324 amino acids, which are not separated by a large linker. The precursor is deposited as keratohyalin granules. During terminal differentiation, it is dephosphorylated and proteolytically cleaved.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005198 structural molecule activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.