HhH-GPD domain (IPR003265)

Short name: HhH-GPD_domain

Overlapping homologous superfamilies

Domain relationships



The HhH-GPD superfamily gets its name from its hallmark helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate [PMID: 10706276, PMID: 8805338]. This domain is found in a diverse range of structurally related DNA repair proteins that include: endonuclease III, EC: and DNA glycosylase MutY, an A/G-specific adenine glycosylase. Both of these enzymes have a C-terminal iron-sulphur cluster loop (FCL). The methyl-CPG binding protein (MBD4) also contain a related domain that is a thymine DNA glycosylase [PMID: 10499592]. The family also includes DNA-3-methyladenine glycosylase II EC:, 8-oxoguanine DNA glycosylases and other members of the AlkA family.

GO terms

Biological Process

GO:0006284 base-excision repair

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.