D-alanine--poly(phosphoribitol) ligase subunit 2 (IPR003230)

Short name: DltC

Family relationships



These proteins are involved in the biosynthesis of D-alanyl-lipoteichoic acid in bacteria. They are major wall and membrane components of most Gram-positive bacteria [PMID: 14665680]. Streptococcus pneumoniae is one of the few species of low-G and C Gram-positive bacteria that do not contain d-alanine in teichoic acids [PMID: 16885447]. d-alanine residues are thought to protect this human pathogen against the actions of cationic antimicrobial peptides. Mammals use antimicrobial peptides to protect themselves from invasive infectious agents such as Group A streptococcus (GAS), which causes necrotising fasciitis and toxic shock syndrome [PMID: 16166534]. Teichoic acids and D-alanylation of teichoic acids are required for colony spreading in Staphylococcus aureus [PMID: 17194792].

GO terms

Biological Process

GO:0019350 teichoic acid biosynthetic process

Molecular Function

GO:0036370 D-alanyl carrier activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.