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Overview
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Cross-references
Transcription initiation factor TFIID subunit 12 domain (IPR003228)
Short name: TFIID_TAF12_dom
Overlapping homologous superfamilies
- Histone-fold (IPR009072)
Domain relationships
None.
Description
TFIID is one of the seven General Transcription Factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIID) that are involved in accurate initiation of transcription by RNA polymerase II in eukaryotes. TFIID plays an important role in the recognition of promoter DNA and assembly of the pre-initiation complex. Human transcription initiation factor TFIID is composed of the TATA-binding protein (TBP) and at least 13 TBP-associated factors (TAFs) that collectively or individually are involved in activator-dependent transcription [PMID: 7667268, PMID: 10664584].
TBP-associated factor 12 (TAF12) is one of several TAFs that bind TBP and are involved in forming the TFIID complex. TAF12 interacts with TAF4 and makes a novel histone-like heterodimer that binds DNA and has a core promoter function of a subset of genes [PMID: 19635797].
This entry represents a domain found in TAF12.
GO terms
Biological Process
GO:0006352 DNA-templated transcription, initiation
Molecular Function
No terms assigned in this category.
Cellular Component
GO:0005669 transcription factor TFIID complex