Domain

Transcription initiation factor TFIID, subunit 12 (IPR003228)

Short name: TFIID_TAF12

Domain relationships

  • Histone-fold (IPR009072)
    • Transcription initiation factor TFIID, subunit 12 (IPR003228)

Description

TFIID is one of the seven General Transcription Factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIID) that are involved in accurate initiation of transcription by RNA polymerase II in eukaryotes. TFIID plays an important role in the recognition of promoter DNA and assembly of the pre-initiation complex. Human transcription initiation factor TFIID is composed of the TATA-binding protein (TBP) and at least 13 TBP-associated factors (TAFs) that collectively or individually are involved in activator-dependent transcription [PMID: 7667268, PMID: 10664584].

TBP-associated factor 12 (TAF12) is one of several TAFs that bind TBP and are involved in forming the TFIID complex. TAF12 interacts with TAF4 and makes a novel histone-like heterodimer that binds DNA and has a core promoter function of a subset of genes [PMID: 19635797].

GO terms

Biological Process

GO:0006352 DNA-templated transcription, initiation

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005669 transcription factor TFIID complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
ProDom
CDD