Family

Methenyltetrahydromethanopterin cyclohydrolase (IPR003209)

Short name: METHMP_CycHdrlase

Family relationships

None.

Description

Methenyltetrahydromethanopterin cyclohydrolase (EC:3.5.4.27) catalyses the interconversion of methenyltetrahydromethanopterin and N(5)formyltetrahydromethanopterin, and is found in both archaea and bacteria. In methanogenic archaea, such as Methanobacterium thermoautotrophicum (strain Marburg / DSM 2133), this enzyme is involved in the production of methane from carbon dioxide [PMID: 8617278]. In the sulphate-reducer Archaeoglobus fulgidus, this enzyme is involved in the tetrahydromethanopterin-dependent oxidation of lactate [PMID: 8481088]. In Gram-negative methylotrophic bacteria this enzyme is involved in the tetrahydromethanopterin-dependent oxidation of formaldehyde to formate [PMID: 10482517]. The protein functions as a homodimer or homotrimer, depending on the organism.

GO terms

Biological Process

GO:0006730 one-carbon metabolic process

Molecular Function

GO:0018759 methenyltetrahydromethanopterin cyclohydrolase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
TIGRFAMs
Pfam
HAMAP