Domain

Diol/glycerol dehydratase, large subunit (IPR003206)

Short name: Diol/glycerol_deHydtase_lsu

Domain relationships

None.

Description

This entry represents the large subunit of adenosylcobalamin-dependent diol dehydratases (EC:4.2.1.28) and glycerol dehydratases (EC:4.2.1.30). These enzymes are produced by some enterobacteria in response to growth substances. The enzyme have an TIM beta/alpha barrel fold [PMID: 10903944]. Inactivated holoenzymes are reactivated by their own reactivating factors that mediate the ATP-dependent exchange of an enzyme-bound, damaged cofactor for free adenosylcobalamin through intermediary formation of apoenzyme. The reactivation takes place in two steps: (a) ADP-dependent cobalamin release and (b) ATP-dependent dissociation of the resulting apoenzyme-reactivating factor complexes [PMID: 17916188].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0031419 cobalamin binding
GO:0016836 hydro-lyase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
PIRSF
Pfam
ProDom
  • PD025428 (Diol/glycerol_deHydtase_lsu)