Cytochrome c oxidase subunit VIIa, metazoa (IPR003177)

Short name: Cytc_oxidase_su7a_met

Overlapping homologous superfamilies

Family relationships


Cytochrome c oxidase (EC: is an oligomeric enzymatic complex which is a component of the respiratory chain complex and is involved in the transfer of electrons from cytochrome c to oxygen [PMID: 6307356]. In eukaryotes this enzyme complex is located in the mitochondrial inner membrane; in aerobic prokaryotes it is found in the plasma membrane.

In eukaryotes, in addition to the three large subunits, I, II and III, that form the catalytic centre of the enzyme complex, there are a variable number of small polypeptidic subunits. This family is composed of the heart and liver isoforms of cytochrome c oxidase subunit VIIa. Subunit VIIa has two tissue-specific isoforms that are expressed in a developmental manner. VIIa-H is expressed in heart and skeletal muscle but not smooth muscle. VIIa-L is expressed in liver and non-muscle tissues [PMID: 9752724].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004129 cytochrome-c oxidase activity
GO:0009055 electron transfer activity

Cellular Component

GO:0005746 mitochondrial respirasome

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.