Methylenetetrahydrofolate reductase (IPR003171)

Short name: Mehydrof_redctse

Overlapping homologous superfamilies

Family relationships


This family includes the 5,10-methylenetetrahydrofolate reductase from bacteria and methylenetetrahydrofolate reductase from eukaryotes (EC: The bacterial enzyme is a homotetramer and NADH is the preferred reductant while the eukaryotic enzyme is a homodimer and NADPH is the preferred reductant. In humans, there are several clinically significant mutations in MTHFR that result in hyperhomocysteinemia, which is a risk factor for the development of cardiovascular disease [PMID: 10201405].

GO terms

Biological Process

GO:0006555 methionine metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.