Pathways & interactions
Transcription regulator HTH, APSES-type DNA-binding domain (IPR003163)
Short name: Tscrpt_reg_HTH_APSES-type
The APSES (ASM-1, Phd1, StuA, EFG1, and Sok2) domain is a ~110-residue sequence-specific DNA-binding domain found in a family of fungal transcription factors that regulate development or cell cycle progression. The APSES domain is found associated with ankyrin repeats (see PDOC50088, IPR002110) and a heterodimerization domain [PMID: 8913744, PMID: 9312029].
The APSES domain consists of a six-stranded beta-sheet segment folded against two pairs of alpha-helices in the topology of the winged helix-turn-helix (HTH) family of proteins [PMID: 9083114]. The alphaA/alphaB helical pair corresponds to the HTH motif [PMID: 9083114, PMID: 9299332, PMID: 12564929]. Some proteins known to contain an APSES domain are listed below:
- Saccharomyces cerevisiae (Baker's yeast) Mlu-1 box binding protein (MBP1, P39678); Mlu-1 and Swi6 together make up the transcription factor complex MBF (Mlu-1-binding factor), which binds to the Mlu1 cell-cycle box (MCB) elements found in the promoters of many DNA synthesis genes [PMID: 12564929].
- Schizosaccharomyces pombe (Fission yeast) cell division cycle-related proteins res1/sct1 (P33520) and res2/pct1 (P41412), which are homologous to MBP1.
- S. pombe start control protein cdc10 (P01129).
- Emericella nidulans (Aspergillus nidulans) cell pattern formation-associated protein stuA (P36011). It regulates the transformation of undifferentiated hyphal elements into a complex multicellular structure.
- S. cerevisiae transcription factor PHD1 (P36093).
- S. cerevisiae protein SOK2 (P53438). It represses the transition from unicellular growth to pseudohyphae.
- Candida albicans (Yeast) enhanced filamentous growth protein (EFG1, P43064)).
- Neurospora crassa ascospore maturation 1 protein (Asm-1, Q92251). It has a role in spore maturation.