Carboxypeptidase, activation peptide (IPR003146)

Short name: M14A_act_pep

Overlapping homologous superfamilies

Domain relationships



The peptidases are synthesised as inactive molecules, zymogens, with propeptides that must be removed by proteolytic cleavage to activate the enzyme. Structural studies of carboxypeptidases A and B reveal the propeptide to exist as a globular domain, followed by an extended alpha-helix; this shields the catalytic site, without specifically binding to it, while the substrate-binding site is blocked by making specific contacts [PMID: 7674922, PMID: 1548696].

This entry represents a propeptide associated with peptidases belonging to MEROPS peptidase family M14A. It is found in the carboxypeptidases A [PMID: 9384570] and B [PMID: 12162965].

Carboxypeptidases are found in abundance in pancreatic secretions. The pro-segment moiety (propeptide or activation peptide) accounts for up to a quarter of the total length of the peptidase.

GO terms

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004180 carboxypeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.