Biotin protein ligase, C-terminal (IPR003142)

Short name: BPL_C

Overlapping homologous superfamilies


Domain relationships



This C-terminal domain has an SH3-like barrel fold, the function of which is unknown. It is found associated with prokaryotic bifunctional transcriptional repressors [PMID: 2642476] and eukaryotic enzymes involved in biotin utilization [PMID: 7842009, PMID: 9173880].

In Escherichia coli the biotin operon repressor (BirA) is a bifunctional protein. BirA acts both as the acetyl-coA carboxylase biotin holoenzyme synthetase (EC: and as the biotin operon repressor. DNA sequence analysis of mutations indicates that the helix-turn-helix DNA binding region is located at the N terminus while mutations affecting enzyme function, although mapping over a large region, are found mainly in the central part of the protein's primary sequence [PMID: 2642476].

GO terms

Biological Process

GO:0006464 cellular protein modification process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.