PA domain (IPR003137)

Short name: PA_domain

Overlapping homologous superfamilies


Domain relationships


The PA (Protease associated) domain is found as an insert domain in diverse proteases, which include the MEROPS peptidase families A22B, M28, and S8A [PMID: 7674922]. The PA domain is also found in a plant vacuolar sorting receptor O22925 and members of the RZF family, e.g. O43567. It has been suggested that this domain forms a lid-like structure that covers the active site in active proteases, and is involved in protein recognition in vacuolar sorting receptors [PMID: 11246007].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.