Lon, substrate-binding domain (IPR003111)

Short name: Lon_substr-bd

Overlapping homologous superfamilies

Domain relationships



This signature defines the N-terminal substrate-binding domain of the archael, bacterial and eukaryotic lon proteases, which are ATP-dependent serine peptidases belonging to the MEROPS peptidase family S16 (lon protease family, clan SF). In the eukaryotes the majority of the proteins are located in the mitochondrial matrix [PMID: 8248235, PMID: 9620272]. In yeast, Pim1, is located in the mitochondrial matrix, is required for mitochondrial function, is constitutively expressed but is increased after thermal stress, suggesting that Pim1 may play a role in the heat shock response [PMID: 8276800].

This structure of this domain has been determined [PMID: 16199667, PMID: 19191354, PMID: 20834233]. This domain also occurs in proteins which lack the peptidase domain, such as the SPBC14F5.10c gene product from Schizosaccharomyces pombe; these proteins are uncharacterized.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles