Prephenate dehydrogenase (IPR003099)

Short name: Prephen_DH

Overlapping homologous superfamilies

Domain relationships



This entry represents prephenate dehydrogenase (PDHG) EC:, an enzyme involved in tyrosine biosynthesis [PMID: 21798280].

Three enzymes catalyse the conversion of chorismate to hydroxyphenylpyruvate or pyruvate in the aromatic amino acid biosynthesis pathway. In this pathway, chorismate is a branch point intermediate that is converted to tryptophan, phenylalanine (Phe), and tyrosine (Tyr). In bacteria the enzymes, chorismate mutase (CM), prephenate dehydratase (PDT), and prephenate dehydrogenase (PDHG) are either present as distinct proteins or fusions combining two activities [PMID: 20944228]. In the archaea Archaeoglobus fulgidus a single protein (AroQ) contains all three enzymatic domains [PMID: 19082689].

GO terms

Biological Process

GO:0055114 oxidation-reduction process
GO:0006571 tyrosine biosynthetic process

Molecular Function

GO:0008977 prephenate dehydrogenase (NAD+) activity
GO:0004665 prephenate dehydrogenase (NADP+) activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles