Keratin, type II (IPR003054)

Short name: Keratin_II

Overlapping homologous superfamilies


Family relationships


Intermediate filaments (IF) [PMID: 8771189, PMID: 3052284, PMID: 2183847] are proteins which are primordial components of the cytoskeleton and the nuclear envelope. They generally form filamentous structures 8 to 14 nm wide.

Type II keratins are the basic or neutral courterparts to the acidic type I keratins. Each type II keratin forms a heterodimer with a specific acidic keratin, and the heterodimers are organised into tetramers and then into chains [PMID: 2183847]. Type II keratins consist of head-, rod- and tail-like structures, the rod being constructed from three linked coils: 1A, 1B and 2. The head and tail structures of the type 2 keratins are highly variable low-complexity regions.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0045095 keratin filament

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.