Conserved Site

Uroporphiryn-III C-methyltransferase, conserved site (IPR003043)

Short name: Uropor_MeTrfase_CS

Description

S-adenosyl-L-methionine-dependent uroporphyrinogen III C-methyltransferase (SUMT; EC:2.1.1.107) is likely to be involved in the biosynthesis of siroheme and cobalamin [PMID: 1856165]. Siroheme, the prosthetic group for both nitrite and sulphite reductases, is a methylated, iron-containing modified tetrapyrrole. This enzyme is found in a wide taxonomic range: archaebacteria, eukaryotes and bacteria.

S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferase from Arabidopsis thaliana may catalyze transmethylation in a multistep process involving the formation of a covalently linked complex with S-adenosyl-L-methionine. The product has a sequence at the amino terminus that resembles a transit peptide for localization to mitochondria or plastids [PMID: 9006913].

GO terms

Biological Process

GO:0055114 oxidation-reduction process
GO:0006779 porphyrin-containing compound biosynthetic process

Molecular Function

GO:0008168 methyltransferase activity
GO:0043115 precorrin-2 dehydrogenase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns