Family

DAD/Ost2 (IPR003038)

Short name: DAD/Ost2

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Members of this family are thought to be integral membrane proteins. Some members of this family have been shown to cause apoptosis if mutated [PMID: 8413235], these proteins are known as DAD for defender against death. The family also includes the epsilon subunit of the oligosaccharyltransferase that is involved in N-linked glycosylation (also known as Ost2) [PMID: 7593165].

DAD1/Ost2 is a component of the N-oligosaccharyl transferase enzyme which catalyses the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains [PMID: 9167970].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity

Cellular Component

GO:0016021 integral component of membrane
GO:0008250 oligosaccharyltransferase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PIRSF
PANTHER