Domain

SCP2 sterol-binding domain (IPR003033)

Short name: SCP2_sterol-bd_dom

Domain relationships

Description

This domain is involved in binding sterols, and is found in proteins such as SCP2. This domain has a 3-layer alpha/beta/alpha fold, composed of alpha/beta(3)/(crossover)/beta/(alpha)/beta.

The human sterol carrier protein 2 (SCP2) is a basic protein that is believed to participate in the intracellular transport of cholesterol and various other lipids [PMID: 8243660]. The Unc-24 protein of Caenorhabditis elegans contains a domain similar to part of two ion channel regulators (the erythrocyte integral membrane protein stomatin and the C. elegans neuronal protein MEC-2) juxtaposed to a domain similar to nonspecific lipid transfer protein (nsLTP; also called sterol carrier protein 2) [PMID: 8667025].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
GENE3D
SUPERFAMILY