Cell cycle checkpoint protein, Rad1 (IPR003011)

Short name: Cell_cycle_checkpoint_Rad1

Overlapping homologous superfamilies


Family relationships

  • Rad1/Rec1/Rad17 (IPR003021)
    • Cell cycle checkpoint protein, Rad1 (IPR003011)


Rad1 is a component of the 9-1-1 cell-cycle checkpoint response complex, which plays a role in checkpoint activation that permits DNA-repair pathways to prevent cell cycle progression in response to DNA damage and replication stress [PMID: 9311982, PMID: 21978893]. The 9-1-1 complex is recruited to DNA lesions upon damage by the Rad17 (Rad24 in budding yeast)-replication factor C (RFC) clamp loader complex. The 9-1-1 complex is necessary for the recruitment of C12orf32/RHINO to sites of double-stranded breaks (DSB) occurring during the S phase [PMID: 21659603]. Rad1 isoform 1 possesses 3'->5' double stranded DNA exonuclease activity [PMID: 9660799].

In Caenorhabditis elegans, the cell cycle checkpoint protein RAD1 homologue mrt-2 has a role in genome stability by promoting DNA double strand break-induced cell cycle arrest and apoptosis, and is required for maintaining telomere length and germline immortality [PMID: 10882129, PMID: 10646593, PMID: 16951081].

GO terms

Biological Process

GO:0000077 DNA damage checkpoint

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.