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Overview
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Pathways & interactions
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Cross-references
GspF/PilC family (IPR003004)
Short name: GspF/PilC
Overlapping homologous superfamilies
None.
Family relationships
- GspF/PilC family (IPR003004)
- General secretion pathway protein F (IPR011850)
Description
The general (type II) secretion pathway (Gsp) within Gram-negative bacteria is a signal sequence-dependent process responsible for protein export [PMID: 8438237, PMID: 1365398, PMID: 1592799]. The process has two stages: exoproteins are first translocated across the inner membrane by the general signal-dependent export pathway (GEP), and then across the outer membrane by a species-specific accessory mechanism.
The Gsp is a composite of several proteins, one of which is termed general secretion pathway protein F (GspF), which is thought to be located within the inner membrane [PMID: 1588814]. This suggests that protein F is part of the GEP apparatus, which aids translocation of exoproteins from the cytoplasm to the periplasm, prior to transport across the outer membrane. GspF is a highly hyrdophobic protein containing ~400 amino acids.
This entry represents GspD and close homologues, including the type IV pilin assembly protein PilC.