GspF/PilC family (IPR003004)

Short name: GspF/PilC

Overlapping homologous superfamilies


Family relationships


The general (type II) secretion pathway (Gsp) within Gram-negative bacteria is a signal sequence-dependent process responsible for protein export [PMID: 8438237, PMID: 1365398, PMID: 1592799]. The process has two stages: exoproteins are first translocated across the inner membrane by the general signal-dependent export pathway (GEP), and then across the outer membrane by a species-specific accessory mechanism.

The Gsp is a composite of several proteins, one of which is termed general secretion pathway protein F (GspF), which is thought to be located within the inner membrane [PMID: 1588814]. This suggests that protein F is part of the GEP apparatus, which aids translocation of exoproteins from the cytoplasm to the periplasm, prior to transport across the outer membrane. GspF is a highly hyrdophobic protein containing ~400 amino acids.

This entry represents GspD and close homologues, including the type IV pilin assembly protein PilC.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.