InterPro

The general (type II) secretion pathway (Gsp) within Gram-negative bacteria is a signal sequence-dependent process responsible for protein export [PMID: 8438237, PMID: 1365398, PMID: 1592799]. The process has two stages: exoproteins are first translocated across the inner membrane by the general signal-dependent export pathway (GEP), and then across the outer membrane by a species-specific accessory mechanism.

The Gsp is a composite of several proteins, one of which is termed general secretion pathway protein F (GspF), which is thought to be located within the inner membrane [PMID: 1588814]. This suggests that protein F is part of the GEP apparatus, which aids translocation of exoproteins from the cytoplasm to the periplasm, prior to transport across the outer membrane. GspF is a highly hyrdophobic protein containing ~400 amino acids.

This entry represents GspD and close homologues, including the type IV pilin assembly protein PilC.