Pathways & interactions
Short name: TNF_C
- Tumour necrosis factor (IPR006053)
- Lymphotoxin-beta (IPR002961)
Cytokines can be grouped into a family on the basis of sequence, functional and structural similarities [PMID: 8095800, PMID: 1377364, PMID: 15335677]. Tumor necrosis factor (TNF) (also known as TNF-alpha or cachectin) is a monocyte-derived cytotoxin that has been implicated in tumour regression, septic shock and cachexia [PMID: 2989794, PMID: 3349526]. The protein is synthesised as a prohormone with an unusually long and atypical signal sequence, which is absent from the mature secreted cytokine [PMID: 2268312]. A short hydrophobic stretch of amino acids serves to anchor the prohormone in lipid bilayers [PMID: 2777790]. Both the mature protein and a partially-processed form of the hormone are secreted after cleavage of the propeptide [PMID: 2777790].
There are a number of different families of TNF, but all these cytokines seem to form homotrimeric (or heterotrimeric in the case of LT-alpha/beta) complexes that are recognised by their specific receptors.
Lymphotoxin-alpha (LT-alpha or TNF-beta) and lymphotoxin-beta (LT-beta) are related cytokines produced by lymphocytes. The proteins are cytotoxic for a wide range of tumour cells in vitro and in vivo. This entry represents Tumour necrosis factor C (TNFC or LT-beta). The gene is found next to the TNF-LT locus in the major histocompatibility complex (MHC), a region of the MHC with possible linkage to autoimmune disease [PMID: 7916655]. It is possible that a surface LT-alpha/LT-beta complex may have a specific role in immune regulation distinct from the functions ascribed to TNF [PMID: 7916655].
- PR01237 (TNFC)