Intracellular chloride channel (IPR002946)

Short name: CLIC

Overlapping homologous superfamilies

Family relationships


The chloride intracellular channel (CLIC) family represent a subgroup of the glutathione-S-transferase (GSTs) superfamily. CLIC proteins can exist as both soluble globular proteins and integral membrane proteins with ion channel function [PMID: 12202911]. Membrane insertion seems to be redox-regulated [PMID: 14613939] and has a strong pH dependence [PMID: 11978800]. CLIC proteins are enigmatic as they do not fit the patterns of other, well-characterised ion channel proteins that show clear and often multiple TM domains [PMID: 20085760]. They share a conserved C-terminal CLIC module, with several members containing additional, unrelated N-terminal domains. CLIC proteins are highly conserved in vertebrates, which usually possess six distinct paralogues (CLIC1-CLIC6) [PMID: 20085760]. They are multifunctional proteins and participate in a wide variety of signaling activities.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.