Myosin tail (IPR002928)

Short name: Myosin_tail

Overlapping homologous superfamilies


Domain relationships



Muscle contraction is caused by sliding between the thick and thin filaments of the myofibril. Myosin is a major component of thick filaments and exists as a hexamer of 2 heavy chains [PMID: 1939027], 2 alkali light chains, and 2 regulatory light chains. The heavy chain can be subdivided into the N-terminal globular head and the C-terminal coiled-coil rod-like tail, although some forms have a globular region in their C-terminal. There are many cell-specific isoforms of myosin heavy chains, coded for by a multi-gene family [PMID: 2806546]. Myosin interacts with actin to convert chemical energy, in the form of ATP, to mechanical energy [PMID: 3540939]. The 3-D structure of the head portion of myosin has been determined [PMID: 8316857] and a model for actin-myosin complex has been constructed [PMID: 8316858].

This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament [PMID: 3783701]. The coiled-coil region provides the structural backbone of the thick filament [PMID: 3783701].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003774 motor activity

Cellular Component

GO:0016459 myosin complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.