Family

Adenovirus small t-antigen, E1B 19kDa protein (IPR002924)

Short name: Adenovir_t-Ag_E1B_19kDa

Family relationships

None.

Description

This family consists of adenovirus E1B 19 kDa protein or small t-antigen. The E1B 19 kDa protein inhibits E1A induced apoptosis and hence prolongs the viability of the host cell [PMID: 8083992]. It can also inhibit apoptosis mediated by tumour necrosis factor alpha and Fas antigen [PMID: 8083992]. E1B 19 kDa blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein [PMID: 8600029]. The E1B region of adenovirus encodes two proteins E1B 19 kDa the small t-antigen as found in this family and E1B 55 kDa the large t-antigen which is not found in this family; both of these proteins inhibit E1A induced apoptosis [PMID: 8083992].

GO terms

Biological Process

GO:0043066 negative regulation of apoptotic process

Molecular Function

GO:0005521 lamin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam