Domain

Pollen allergen Poa pIX/Phl pVI, N-terminal (IPR002914)

Short name: POA_allergen_N

Domain relationships

None.

Description

Allergies are hypersensitivity reactions of the immune system to specific substances called allergens (such as pollen, stings, drugs, or food) that, in most people, result in no symptoms. A nomenclature system has been established for antigens (allergens) that cause IgE-mediated atopic allergies in humans [WHO/IUIS Allergen Nomenclature Subcommittee King T.P., Hoffmann D., Loewenstein H., Marsh D.G., Platts-Mills T.A.E., Thomas W. Bull. World Health Organ. 72:797-806(1994)]. This nomenclature system is defined by a designation that is composed of the first three letters of the genus; a space; the first letter of the species name; a space and an arabic number. In the event that two species names have identical designations, they are discriminated from one another by adding one or more letters (as necessary) to each species designation.

The allergens in this family include allergens with the following designations: Lol p 5, Pha a 5, Phl p 5, Phl p 6, Phl p 11 and Poa p 9.

Grass pollen allergens are one of the major causes of type I allergies (including allergic rhinoconjunctivitis, allergic bronchial asthma and hayfever), afflicting 15-20% of a genetically predisposed population [PMID: 1702432]. The predicted molecular masses of the known pollen allergen proteins range from 28.3 to 37.8kDa [PMID: 1702432]. Northern analysis indicates that expression of the genes is confined to pollen tissue. A low level of similarity is observed between the Phl p 5 allergens and the N-terminal sequences of Poa pratensis (Kentucky bluegrass) p 9 proteins [PMID: 2051020] (see IPR001778).

The N-terminal region of P. pratensis p 9 has been shown to possess epitopes that cross-react with the acidic group V allergens of Phleum pratense (Common timothy) [PMID: 2051020]. Comparison of amino acid sequences of recombinant P. pratensis p 9 proteins with those of Lol p 5 isoallergens revealed a low level of similarity between the N-terminal sequences of these proteins [PMID: 2051020]. A C-terminal region (IPR001778), conserved in P. pratensis p 9 allergens, appears to contain epitopes unique to these proteins [PMID: 2051020].

GO terms

Biological Process

GO:0016068 type I hypersensitivity

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
GENE3D
SUPERFAMILY