Family

Probable pantothenate synthetase/4-phosphopantoate--beta-alanine ligase (IPR002855)

Short name: PPS

Family relationships

None.

Description

Proteins in this family include pantothenate synthetase (EC:6.3.2.n5) from Methanosarcina mazei and 4-phosphopantoate--beta-alanine ligase (EC:6.3.2.36) from Pyrococcus kodakaraensis. Pantothenate synthetase catalyses the condensation of pantoate with beta-alanine in an ATP-dependent and ADP-producing reaction [PMID: 18422645]. 4-phosphopantoate--beta-alanine ligase catalyses the conversion of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway. It cannot use (R)-pantoate as substrate and thus does not display pantothenate synthetase (PS) activity [PMID: 19666462].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
ProDom
Pfam
PIRSF