Family

Translin family (IPR002848)

Short name: Translin_fam

Family relationships

  • Translin family (IPR002848)

Description

Translins are DNA-binding proteins that specifically recognise consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. They seem to recognise single-stranded DNA ends generated by staggered breaks occuring at recombination hot spots [PMID: 9013868]. Translin folds into an alpha-alpha superhelix, consisting of two curved layers of alpha/alpha topology [PMID: 12079346, PMID: 15039555].

This entry also includes translin-associated protein X (TRAX), which was found to interact with translin [PMID: 9013868, PMID: 12036294].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0043565 sequence-specific DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
Pfam