PDCD5-like (IPR002836)

Short name: PDCD5-like

Overlapping homologous superfamilies

Family relationships


This protein family is found in archaea and eukaryota. Proteins in this family contain a predicted DNA-binding domain [PMID: 11017201] and may function as DNA-binding proteins. Methanobacterium thermoautotrophicum MTH1615 was predicted to bind DNA based on structural proteomics data, and this was confirmed by the demonstration that it can interact non-specifically with a randomly chosen 20-mer of double stranded DNA [PMID: 11017201]. This suggests that the human protein may be involved in nucleic acid binding or metabolism.

The human programmed cell death protein 5 (PDCD5, also known as TFAR19) encodes a protein which shares significant homology to the corresponding proteins of species ranging from yeast to mice. PDCD5 exhibits a ubiquitous expression pattern and its expression is up-regulated in the tumour cells undergoing apoptosis. PDCD5 may play a general role in the apoptotic process [PMID: 9920759, PMID: 19358820].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.