Family

UbiD decarboxylyase family (IPR002830)

Short name: UbiD

Family relationships

Description

This family of proteins is found in prokaryotes, archaea and fungi, with two members in Archaeoglobus fulgidus. They are related to UbiD, a 3-octaprenyl-4-hydroxybenzoate carboxy-lyase (also known as polyprenyl p-hydroxybenzoate decarboxylase) from Escherichia coli that is involved in ubiquinone biosynthesis [PMID: 11029449]. The member from Helicobacter pylori has a C-terminal extension of just over 100 residues that is shared, in part, by the Aquifex aeolicus homologue.

Proteins in this entry includes:

  • Bacterial UbiD that catalyses the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol. It is involved in ubiquinone biosynthesis [PMID: 11029449].
  • Budding yeast Fdc1 that catalyses the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites [PMID: 20471595, PMID: 25647642]. Fdc1 is not essential for ubiquinone synthesis [PMID: 20471595].
  • 4-hydroxybenzoate decarboxylase subunit C (also known as HBDC) that catalyses the reversible decarboxylation of 4-hydroxybenzoate [PMID: 17211544].
  • Phenolic acid decarboxylase subunit C (YclC) that can catalyse the reversible decarboxylation of 4-hydroxybenzoate and vanillate [PMID: 10438791, PMID: 7744052, PMID: 15979273] and can also decarboxylate 3,4-dihydroxybenzoate [PMID: 7744052].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016831 carboxy-lyase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
TIGRFAMs