Hydantoinase A/oxoprolinase (IPR002821)

Short name: Hydantoinase_A

Overlapping homologous superfamilies


Domain relationships



This domain is found in the enzymes hydantoinase A (HyuA) and oxoprolinase (EC: Both enzymes catalyse reactions involving the hydrolysis of 5-membered rings via hydrolysis of their internal imide bonds [PMID: 8943290]. This domain is also found in (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase from Methanocaldococcus jannaschii, which is involved in methanofuran biosynthesis, catalyzing the condensation between 5-(aminomethyl)-3-furanmethanol diphosphate and gamma-glutamyltyramine to produce 4-[N-(gamma-L-glutamyl)-p-(beta-aminoethyl)phenoxymethyl]-(aminomethyl)furan (APMF-Glu) [PMID: 26100040]. D-5-(2-methylthioethyl)hydantoin amidohydrolase (HyuA) from Pseudomonas is a component of the hydantoinase process, an enzymatic cascade converting D-5-(2-methylthioethyl)hydantoin to N-carbamoyl-D-methionine [PMID: 1732229].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016787 hydrolase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.