Family

Arginine biosynthesis protein ArgJ (IPR002813)

Short name: Arg_biosynth_ArgJ

Family relationships

None.

Description

ArgJ (also known as Ornithine acetyltransferase/OAT) is a bifunctional protein that catalyses the first EC:2.3.1.35 and fifth steps EC:2.3.1.1 in arginine biosynthesis [PMID: 8473852], coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in the arginine biosynthetic pathway. The structure has been determined for glutamate N-acetyltransferase 2 (ornithine acetyltransferase; EC:2.3.1.35), an ArgJ-like protein from Streptomyces clavuligerus [PMID: 15352873].

Members of this family may experience feedback inhibition by L-arginine. The active enzyme is a heterotetramer of two alpha and two beta chains, where the alpha and beta chains are the result of autocatalytic cleavage. OATs found in the clavulanic acid biosynthesis gene cluster catalyze the fifth step only, and may utilize acetyl acceptors other than glutamate [PMID: 15375131, PMID: 15352873, PMID: 12633501, PMID: 8473852, PMID: 4365537, PMID: 15937278].

GO terms

Biological Process

GO:0006526 arginine biosynthetic process

Molecular Function

GO:0004358 glutamate N-acetyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
CDD
HAMAP
TIGRFAMs
Pfam