Family

3-dehydroquinate synthase (IPR002812)

Short name: DHQ_synth

Family relationships

None.

Description

3-Dehydroquinate synthase (EC:4.2.3.4) is an enzyme in the common pathway of aromatic amino acid biosynthesis that catalyses the conversion of 3-deoxy-D-arabino-heptulosonic acid 7-phosphate (DAHP) into 3-dehydroquinic acid [PMID: 11173489]. This synthesis of aromatic amino acids is an essential metabolic function for most prokaryotic as well as lower eukaryotic cells, including plants. The pathway is absent in humans; therefore, DHQS represents a potential target for the development of novel and selective antimicrobial agents. Owing to the threat posed by the spread of pathogenic bacteria resistant to many currently used antimicrobial drugs, there is clearly a need to develop new anti-infective drugs acting at novel targets. A further potential use for DHQS inhibitors is as herbicides [PMID: 11412967].

GO terms

Biological Process

GO:0009073 aromatic amino acid family biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0003856 3-dehydroquinate synthase activity
GO:0016491 oxidoreductase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF
HAMAP
ProDom
Pfam