S-adenosylmethionine synthetase, archaea (IPR002795)

Short name: S-AdoMet_synthetase_arc

Overlapping homologous superfamilies


Family relationships


A highly diverged class of S-adenosylmethionine synthetases have been identified in the archaea. S-adenosylmethionine is the primary alkylating agent in all known organisms. ATP:L-methionine S-adenosyltransferase (MAT) catalyses the only known biosynthetic route to this central metabolite. Although the amino acid sequence of MAT is strongly conserved among bacteria and eukarya (see IPR002133) no homologues had been recognised in the completed genome sequences of any archaea. The identification of a second major class of MAT emphasises the long evolutionary history of the archaeal lineage and the structural diversity found even in crucial metabolic enzymes [PMID: 10660563]. Three bacterial genomes encode both the archaeal and eukaryotic/bacterial types of MAT [PMID: 10660563].

GO terms

Biological Process

GO:0006730 one-carbon metabolic process

Molecular Function

GO:0005524 ATP binding
GO:0004478 methionine adenosyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.