Family

Deoxyhypusine synthase (IPR002773)

Short name: Deoxyhypusine_synthase

Overlapping homologous superfamilies

Family relationships

Description

Eukaryotic initiation factor 5A (eIF-5A), now considered to be an elongation factor (see IPR001884), contains an unusual amino acid, hypusine [N epsilon-(4-aminobutyl-2-hydroxy)lysine]. The first step in the post-translational formation of hypusine is catalysed by the enzyme deoxyhypusine synthase (DS, EC:2.5.1.46). The enzyme catalyses the following reaction:

Spermidine + [eIF-5A]-lysine = 1,3-diaminopropane + [eIF-5A]-deoxyhypusine

The modified version of eIF-5A, and DS, are required for eukaryotic cell proliferation [PMID: 9493264]. The structure is known for this enzyme [PMID: 9493264] in complex with its NAD+ cofactor.

GO terms

Biological Process

GO:0008612 peptidyl-lysine modification to peptidyl-hypusine

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
TIGRFAMs
Pfam