CobE/GbiG C-terminal domain (IPR002750)

Short name: CobE/GbiG_C

Overlapping homologous superfamilies

Domain relationships



Cobalt-precorrin-5A hydrolase CbiG is specific for anaerobic cobalamin (vitamin B12) biosynthesis. CbiG, which shows homology with CobE of the aerobic pathway, participates in the conversion of cobalt-precorrin 5 into cobalt-precorrin 6 [PMID: 12196148]. CbiG is responsible for the opening of the delta-lactone ring and extrusion of the C2-unit [PMID: 16866557]. The aerobic pathway uses molecular oxygen to trigger the events at C-20 leading to contraction and expulsion of the C2-unit as acetic acid from a metal-free intermediate, whereas the anaerobic route involves the internal delivery of oxygen from a carboxylic acid terminus to C-20 followed by extrusion of the C2-unit as acetaldehyde, using cobalt complexes as substrates [PMID: 16866557].

This entry represents a domain found at the C terminus of CibG. CobE is composed solely of this domain.

GO terms

Biological Process

GO:0009236 cobalamin biosynthetic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.