Domain

MIP18 family-like (IPR002744)

Short name: MIP18-like

Overlapping homologous superfamilies

Domain relationships

None.

Description

This domain (previously known as DUF59) is found in proteins that are mostly defined as members of the MIP18 family. This includes iron-sulfur cluster carrier proteins, where the domain is found in the N terminus. This domain is also found in protein AE7 from Arabidopsis and its homologues. Protein AE7 is thought to be a central member of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) pathway, however protein AE7-like 1 and 2 (also containing this domain) are probably not involved in this pathway [PMID: 23104832]. MIP18 family protein YHR122W (CIA2) from S. cerevisiae is a component of the CIA machinery, and acts at a late step of Fe-S cluster assembly [PMID: 22678362]. The SufT protein from Staphylococcus aureus is composed of this domain solely and is involved in the maturation of FeS proteins [PMID: 27517714].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam