Desulfoferrodoxin, ferrous iron-binding domain (IPR002742)

Short name: Desulfoferrodoxin_Fe-bd_dom

Overlapping homologous superfamilies

Domain relationships



Desulfoferrodoxins contains two types of iron: an Fe-S4 site very similar to that found in desulfoferrodoxin from Desulfovibrio gigas, and an octahedral coordinated high-spin ferrous site most probably with nitrogen/oxygen-containing ligands. Due to this rather unusual combination of active centres, this novel protein is named desulfoferrodoxin [PMID: 2174880].

The desulfoferrodoxin domain comprises essentially the full length of neelaredoxin (O50258 [PMID: 8001576]), a monomeric, blue, non-haem iron protein of D. gigas said to bind two iron atoms per monomer with identical spectral properties. Neelaredoxin was shown recently to have significant superoxide dismutase activity [PMID: 9914498]. This domain is also found (in a form in which the distance between the motifs H[HWYF]IXW and CN[IL]HGXW is somewhat shorter) as the C-terminal domain of desulfoferrodoxin, which is said to bind a single ferrous iron atom. The N-terminal domain of desulfoferrodoxin is described by IPR004462.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.